BRAP Antibody

BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z569].
BRAP
BRCA1 associated protein
BRCA1-associated protein
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Product
Specifications
Ordering Information
Human
IP
Between 510 and 560
100
$339
$99
Human
WB, IP
Between 560 and 592
100
$339
$229
$99
Human
100
Includes: 1 each of A302-681A and A302-682A
$472
Includes: 1 each of A302-681A and A302-682A