Ric-8A Antibody

RIC8 guanine nucleotide exchange factor A (Ric-8A), also known as Synmebryn-A, is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. It is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Ric-8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). It also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NPQ8].
RIC8A
RIC8 guanine nucleotide exchange factor A
Synembryn-A
:  Protein Ric-8A resistance to inhibitors of cholinesterase 8 homolog A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) RIC8 synembryn synembryn-A
Product
Specifications
Ordering Information
Human
IP
Between 1 to 50
100
$339
$99
Human, Mouse
WB, IP
Between 418 to 468
100
$339
$229
$99
Human, Mouse
100
Includes: 1 each of A304-571A and A304-572A
$472
Includes: 1 each of A304-571A and A304-572A