PRKAR2A/PKA-RIIalpha (cAMP-dependent protein kinase type II-alpha regulatory subunit) is one of 4 isoforms of regulatory subunits of the cAMP-dependent protein kinase (PKA). RI and RII are the two major classes of regulatory subunits. RI and RII each have an alpha and beta isoform. The regulatory subunits perform non-redundant functions as receptors for CAMP signals and for the differential regulation of PKA activity. The PRKAR2A/PKA-RIIalpha functions as an inhibitor of the PKA holoenzyme. PRKAR2A/PKA-RIIalpha subunits have been found to interact with A-kinase anchoring proteins (AKAPs), proteins that function to target the subcellular localization of PKA.
cAMP-dependent protein kinase type II-alpha regulatory subunit
cAMP-dependent protein kinase regulatory subunit RII alpha•
protein kinase A, RII-alpha subunit•
protein kinase, cAMP-dependent, regulatory subunit type II alpha•
protein kinase, cAMP-dependent, regulatory, type II, alpha•