USP1 Antibody

Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 1 (USP1) has been found to play a role in the Fanconi anemia DNA repair pathway. USP1 specifically removes monoubiquitination from the Fanconi anemia D2 (FANCD2) protein and from the proliferating cell nuclear antigen (PCNA). Deubiquitination of FANCD2 and PCNA is critical to their role in the DNA damage response and DNA crosslink repair.
USP1
ubiquitin specific peptidase 1
Ubiquitin carboxyl-terminal hydrolase 1
:  deubiquitinating enzyme 1 hUBP ubiquitin carboxyl terminal hydrolase 1 ubiquitin specific processing protease 1 ubiquitin specific protease 1 ubiquitin thioesterase 1 ubiquitin thiolesterase 1 ubiquitin-specific-processing protease 1 UBP
Product
Specifications
Ordering Information
Human
IP
Between 300 and 350
100
$339
$99
Human
IP, IHC-P
Between 450 and 500
100
$339
$99
Human
IP
Between 584 and 634
100
$339
$99
Human
100
Includes: 1 each of A301-698A, A301-699A and A301-700A
$707
Includes: 1 each of A301-698A, A301-699A and A301-700A
Human
IHC-P
Between 450 and 500
100
$360
$99