SAM domain and HD domain-containing protein 1 (SAMHD1) is a putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. SAMHD1 may play a role in mediating proinflammatory responses to TNF-alpha signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y3Z3].
Aicardi-Goutieres syndrome 5•
dendritic cell-derived IFNG-induced protein•
HD domain containing 1•
monocyte protein 5•
SAM domain and HD domain 1•
SAM domain and HD domain-containing protein 1•