RRP8 Antibody

Ribosomal RNA-processing protein (RRP8) is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43159].
RRP8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Ribosomal RNA-processing protein 8
:  cerebral protein 1 KIAA0409 NML nucleomethylin RRP8 methyltransferase homolog
Product
Specifications
Ordering Information
Human
WB
Between 1 to 50
100
$339
$229
$99
Human
IP
Between 406 to 456
100
$339
$99
Human
100
Includes: 1 each of A304-201A and A304-202A
$472
Includes: 1 each of A304-201A and A304-202A