CSK Antibody

C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P41240].
CSK
c-src tyrosine kinase
Tyrosine-protein kinase CSK
:  C-Src kinase protein-tyrosine kinase CYL
Product
Specifications
Ordering Information
Human
IP
Between 375 to 425
100
$339
$99
Human, Mouse
WB, IP
Between 400 to 450
100
$339
$229
$99
Human, Mouse
100
Includes: 1 each of A304-230A and A304-231A
$472
Includes: 1 each of A304-230A and A304-231A