NIPA Antibody

Nuclear-interacting partner of ALK (NIPA) is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. NIPA may have an antiapoptotic role in NPM-ALK-mediated signaling events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86WB0].
ZC3HC1
zinc finger C3HC-type containing 1
Nuclear-interacting partner of ALK
:  hematopoietic stem/progenitor cell protein 216 hNIPA HSPC216 NIPA nuclear interacting partner of anaplastic lymphoma kinase (ALK) nuclear interaction partner of ALK Nuclear-interacting partner of anaplastic lymphoma kinase Zinc finger C3HC-type protein 1 zinc finger, C3HC-type containing 1 More... Less...
Product
Specifications
Ordering Information
Human
IP
Between 1 and 50
$339
$99
Human
WB, IP
Between 300 and 350
$339
$229
$99
Human
Includes: 1 each of A302-941A and A302-942A
$472
Includes: 1 each of A302-941A and A302-942A