Shwachman-Bodian-Diamond Syndrome/SBDS Antibody

Shwachman-Bodian-Diamond Syndrome/SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, it triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is required for normal levels of protein synthesis. It may play a role in cellular stress resistance and cellular response to DNA damage. It may also play a role in cell proliferation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3A5].
SBDS
SBDS ribosome assembly guanine nucleotide exchange factor
Ribosome maturation protein SBDS
:  CGI-97 FLJ10917 SDS Shwachman-Bodian-Diamond syndrome Shwachman-Bodian-Diamond syndrome protein SWDS
Product
Specifications
Ordering Information
Human
WB, IP
Between 175 and 225
100
$339
$229
$99