Rad18 is an E3 ubiquitin-protein ligase that associates with the E2 ubiquitin conjugating enzyme UBE2B (Rad6b) and monoubiquitinates PCNA on stalled replication forks. This activity promotes the recruitment of DNA repair polymerases such as DNA polymerase eta (Poleta) and translesion synthesis at DNA lesions.
postreplication repair protein hRAD18p•
postreplication repair protein RAD18•
RAD18 E3 ubiquitin protein ligase•
RAD18 homolog (S. cerevisiae)•
RAD18, S. cerevisiae, homolog•
RING finger protein 73•