p14ARF/p16INK4a

p14ARF/p16INK4a is a negative regulator of CDK4 and CDK6 kinase activity and cell cycle progression. p14ARF/p16INK4a regulates the cell cycle by inhibiting cyclin/CDK complex formation and the phosphorylation of the retinoblastoma protein (pRb). p14ARF/p16INK4a is a tumor suppressor associated with malignancies such as melanoma and astrocytoma and is the cause of Li-Fraumeni syndrome.
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