LARG Antibody

LARG (leukemia-associated RhoGEF) is homologous to PDZ-RhoGEF and functions as a RhoA-specific guanine nucleotide exchange factor. RhoGEFs catalyze the exchange of GDP for GTP on the GTPase, Rho, to activate downstream signaling pathways. LARG contains a PDZ [post synaptic density protein (PSD95), Drosophila discs-large tumor suppressor (DIgA), and zonula occludens-1 protein (zo-1)] domain which is an 80-90 amino acid structural domain found in signaling proteins in bacteria, yeast, plants, and animals. LARG is proposed to play a role in cell polarity and microtubule dynamics and may act as a GTPase-activating protein (GAP) for the heterotrimeric Galpha(12) and Galpha(13) proteins.
ARHGEF12
Rho guanine nucleotide exchange factor 12
Rho guanine nucleotide exchange factor 12
:  KIAA0382 LARG leukemia-associated rho guanine nucleotide exchange factor leukemia-associated RhoGEF PRO2792 Rho guanine nucleotide exchange factor (GEF) 12
Product
Specifications
Ordering Information
Human
WB
Between 1350 and 1400
100
$339
$229
$99
Human
WB, IP
Between 1494 and 1544
100
$339
$229
$99
Human
100
Includes: 1 each of A301-959A and A301-960A
$472
Includes: 1 each of A301-959A and A301-960A