IMPA1 Antibody

Inositol monophosphatase 1 (IMPA1) is an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorde [taken from NCBI Entrez Gene (Gene ID: 3612)].
IMPA1
inositol monophosphatase 1
Inositol monophosphatase 1
:  D-galactose 1-phosphate phosphatase IMP IMP 1 IMPA IMPase 1 inositol(myo)-1(or 4)-monophosphatase 1 inositol-1(or 4)-monophosphatase 1 lithium-sensitive myo-inositol monophosphatase A1 myo-inositol monophosphatase 1 testicular tissue protein Li 94
Product
Specifications
Ordering Information
Human
IP
between 25 and 75
100
$339
$99
Human, Mouse
WB, IP
between 227 and 277
100
$339
$229
$99
Human, Mouse
100
Includes: 1 each of A305-427A and A305-428A
$472
Includes: 1 each of A305-427A and A305-428A