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Search Results for "HIF2-alpha"

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Rabbit anti-HIF2-alpha Recombinant Monoclonal Antibody [BL-95-1A2]
Bethyl Laboratories® Catalog # A700-003-T A700-003 A700-003CF

Validated

Rabbit anti-HIF2-alpha Recombinant Monoclonal Antibody [BL-95-1A2]

Validation Performed

Pillar 1: Independent Antibodies
Pillar 2: Complementary Assays
Pillar 5: Protein OE/Epitope Tags

Learn more about the validation performed

Documents (11) Citations ()

Target: HIF2-alpha

Reactivity: Human

Applications:

Host: Rabbit

Clonality: Recombinant Monoclonal

Conjugate:

Purity:

7 Figures

parentCodeBETHYL-A700-003

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Bovine alpha-Lactalbumin ELISA Kit
Bethyl Laboratories® Catalog # E11-128

Documents (3)

Target: Bovine alpha-Lactalbumin

Reactivity: Bovine

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Assay Range: 0.39 – 25 ng/ml

Sample Type: Milk

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1 Figure

parentCodeBETHYL-E11-128

$570.00

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Human Alpha-1-Antitrypsin ELISA Kit
Bethyl Laboratories® Catalog # E88-122

Documents (15) Citations ()

Target: Human Alpha-1-Antitrypsin

Reactivity: Human

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Assay Range: 0.27 - 200 ng/ml

Sample Type: Serum, Plasma, Colostrum, Milk

Conjugate:

Purity:

1 Figure

parentCodeBETHYL-E88-122

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Hypoxia Signaling: HIF1-alpha & HIF2-alpha Recombinant Rabbit Monoclonal Antibodies
Article

The hypoxic response pathway is triggered by low levels of oxygen in the cellular environment. Hypoxia inducible transcription factor (HIF) is central to the hypoxic response. HIF exists as a heterodimeric transcription factor composed of an alpha and beta subunit. In mammals there are three HIF-alpha subunits, HIF1-alpha, HIF2-alpha, and HIF3-alpha, and one beta subunit, the aryl hydrocarbon receptor nuclear translocator (ARNT). The overexpression of HIF1-alpha and HIF2-alpha is associated with poor survival rates for various cancers. Experimental and clinical evidence strongly suggests HIF1-alpha and HIF2-alpha influence tumor development and response to treatment. Because of this, there has been major interest in developing selective HIF inhibitors; but due to the complexity of the HIF pathway, the process has been challenging. Thus, future work for therapeutic targeting of the HIFs will require a better understanding of both the HIF1-alpha and HIF2-alpha pathways.
USP5 promotes breast cancer proliferation and metastasis by stabilizing HIF2α
Article

Hypoxia is often present in solid tumors as cell growth and density increases limiting oxygen diffusion at normal levels to all the cells. While hypoxia and hypoxia inducible factors have been associated with metastasis and poor clinical prognosis, not much has been studied about the regulation of HIF2α in breast cancer. This study identifies USP5 as a novel deubiquitinase for HIF2α, increasing HIF2α stability and transcriptional activity. Together, these proteins increase cell proliferation and metastasis, and their expression positively predicts poor patient outcomes.

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