Drosha is one of three human RNase III enzymes (Drosha, Dicer, and Argonaute) that play a diverse role in the processing and maturation of RNA. Drosha, along with DGCR8 (DeGeorge Syndrome Chromomsomal Region 8, also known as Pasha in C. elegans and D. melanogaster) is a component of the Microprocessor complex. In this complex, Drosha functions as a double-stranded endoribonuclease critical to the first step in the processing of human microRNAs. During this step, Drosha is responsible for cleaving pri-miRNA to yield hairpin-shaped pre-miRNA for futher processing by the cytoplasmic RNase III enzyme, Dicer.
drosha, double-stranded RNA-specific endoribonuclease•
drosha, ribonuclease type III•
nuclear RNase III Drosha•
putative protein p241 which interacts with transcription factor Sp1•
putative ribonuclease III•
ribonuclease III, nuclear•
ribonuclease type III, nuclear•